Weekly issue 2026-W33 ·
Quantitative analysis of d-amino acids in renal samples using derivatization.
Plain language
A new lab method measures mirror-image amino acids in blood, urine and cyst fluid. As kidney disease worsened, one of them (d-serine) rose in blood and fell in urine — a possible future warning signal. Very early, method-stage science.
Clinical note
Analytical-chemistry study (LC-MS/MS with l-FDLA derivatization) in CKD and ADPKD fluids. Plasma d-serine rises while urinary d-serine falls with dysfunction — biomarker hypothesis only, far from clinical use.
Question for your next visit
Which tests are currently reliable for monitoring my kidney function, and how do they differ from experimental markers such as d-serine?